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This document is a supplemental material for the article titled "Time interval from last visit to imaging diagnosis influences outcome in pancreatic adenocarcinoma: A regional population-based study on linked medico-administrative and clinical data" by Vittoria Balzano and colleagues, published in the journal Therapeutic Advances in Medical Oncology. The article investigates how the time gap between the last medical consultation and the imaging diagnosis of pancreatic cancer affects the prognosis and survival of patients. The study uses a large dataset of linked administrative and clinical records from a French region to analyze the characteristics and outcomes of patients with pancreatic adenocarcinoma.
The authors found that the median time interval from last visit to imaging diagnosis was 42 days, and that this interval was significantly associated with tumor stage, resectability, and overall survival. Patients who had a shorter time interval (90 days). The authors also identified several factors that influenced the time interval, such as age, sex, comorbidities, and type of medical consultation.
Quickbooks Activator 30 Users 2013 2014 2015 2016 v.16 64 bit
The study provides valuable insights into the impact of diagnostic delay on pancreatic cancer outcomes and highlights the need for improving the early detection and referral of patients with suspected pancreatic cancer. The authors suggest that reducing the time interval from last visit to imaging diagnosis could improve the prognosis and survival of patients with pancreatic cancer. They also recommend further research to explore the reasons for the diagnostic delay and to evaluate the effectiveness of interventions to shorten it.
The study is one of the few population-based studies that have examined the relationship between time interval from last visit to imaging diagnosis and pancreatic cancer outcomes using linked administrative and clinical data. The authors used a comprehensive dataset that covered all patients diagnosed with pancreatic cancer in a French region over a 10-year period. The dataset included information on patient demographics, comorbidities, tumor characteristics, treatments, and survival. The authors also performed a robust statistical analysis to adjust for potential confounders and to account for competing risks of death.
However, the study also has some limitations that should be acknowledged. First, the study relied on administrative data to define the time interval from last visit to imaging diagnosis, which may not reflect the actual onset of symptoms or the clinical suspicion of pancreatic cancer. Second, the study did not have information on some relevant variables that could affect the time interval and the outcomes, such as tumor biology, genetic factors, patient preferences, and quality of care. Third, the study was conducted in a single region of France, which may limit the generalizability of the findings to other settings and populations. 29c81ba772